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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q7Z434: Variant p.Cys79Phe

Mitochondrial antiviral-signaling protein
Gene: MAVS
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Variant information Variant position: help 79
Type of variant: help LB/B
Residue change: help From Cysteine (C) to Phenylalanine (F) at position 79 (C79F, p.Cys79Phe).
Physico-chemical properties: help Change from medium size and polar (C) to large size and aromatic (F)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 79
Protein sequence length: help 540
Location on the sequence: help FNTLQRRPGWVEYFIAALRG C ELVDLADEVASVYQSYQPRT
Residue conservation: help 
Human                         FNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSY-QPRT

Mouse                         FNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPG

Rat                           FNTLQRRPGWVEVFIRALRICELPGLAEQVTRVYQSYLPPG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 540 Mitochondrial antiviral-signaling protein
Topological domain 1 – 513 Cytoplasmic
Lipidation 79 – 79 S-palmitoyl cysteine
Alternative sequence 1 – 141 Missing. In isoform 4.
Alternative sequence 40 – 131 DRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYN -> GPRTVPQTHWSHRHFLLRGQGPPHLLRPTASPTTAAERRSQVTPCLSRRPRRQSPQERIQSKPCRRSAPEPSQGIQMVAPWSPPLTWQPSAL. In isoform 6.
Alternative sequence 64 – 148 RRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQ -> LPTWAGEETPGGQSSGRGLDFSSLTSGAVWLWQMSDFWSCFSTWTVSIWLILHWVLLRLNLQVFAKCLAQSKWPLLLPSLSCPTW. In isoform 3.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.