Variant position: 198 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 540 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LESSSDLAALSPLTSSGHQE QDTELGSTHTAGATSSLTPSR
Mouse LIPSPNQQALSPQPSREHQE QEPELGGAHAANVASVPIATY
Rat LISSPNPPALSPQPSREHPE QEPELGGPSTANVDSVPIATY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 540 Mitochondrial antiviral-signaling protein
1 – 513 Cytoplasmic
180 – 180 Phosphoserine
188 – 188 Phosphoserine
215 – 215 Phosphothreonine
125 – 540 Missing. In isoform 5.
132 – 540 Missing. In isoform 2 and isoform 6.
149 – 540 Missing. In isoform 3.
196 – 196 Q -> A. No effect on cleavage by Seneca Valley virus protease 3C.
198 – 198 Q -> A. No effect on cleavage by Seneca Valley virus protease 3C.
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
Seth R.B.; Sun L.; Ea C.-K.; Chen Z.J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; TISSUE SPECIFICITY; MUTAGENESIS OF THR-54 AND 67-GLY--VAL-69; INTERACTION WITH DDX58/RIG-I AND TRAF6; SUBCELLULAR LOCATION; VARIANTS LYS-198 AND PHE-409;
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Meylan E.; Curran J.; Hofmann K.; Moradpour D.; Binder M.; Bartenschlager R.; Tschopp J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH DDX58/RIG-I; IKBKE; CHUK AND IKBKB; FUNCTION; CLEAVAGE SITE; MUTAGENESIS OF CYS-508; VARIANTS LYS-198 AND PHE-409;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS GLU-93; LYS-198 AND PHE-409;
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