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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P42574: Variant p.His22Arg

Caspase-3
Gene: CASP3
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Variant information Variant position: help 22
Type of variant: help LB/B
Residue change: help From Histidine (H) to Arginine (R) at position 22 (H22R, p.His22Arg).
Physico-chemical properties: help Change from medium size and polar (H) to large size and basic (R)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 22
Protein sequence length: help 277
Location on the sequence: help ENTENSVDSKSIKNLEPKII H GSESMDSGISLDNSYKMDYP
Residue conservation: help 
Human                         ENTENSV-------DSKSIKNLEPKIIHGSESMD----SGISLDNSYKMDYP

                              ENTENSV-------DAKSFKNAETKILHGSKSMD----SGM

Chimpanzee                    ENTENSV-------DSKSIKNLEPKIIHGSQSMD----SGI

Mouse                         ENNKTSV-------DSKSINNFEVKTIHGSKSVD----SGI

Rat                           DNNETSV-------DSKSINNFETKTIHGSKSMD----SGI

Pig                           ENNKTSV-------DSKSIKTLETKILHGSKSMD----SGI

Bovine                        ENTENSV-------DSKSIKTSETKILHGSKSMD----SGI

Rabbit                        ENNETSV-------DAKSIKNLETQTIHGSKSMD----SGK

Cat                           ENSENSV-------DAKSIKNSETKIFHGSKSMD----SGI

Xenopus laevis                EESQNGVKYGGDATDAKEYFTIQPRSLQNCDLKDIERKTKF
Sequence annotation in neighborhood: help
TypePositionsDescription
Propeptide 10 – 28
Modified residue 11 – 11 N6-acetyllysine
Modified residue 26 – 26 Phosphoserine
Mutagenesis 9 – 9 D -> A. In P3-D3A mutant; abolished cleavage and activation, leading to prevent thiol protease activity; when associated with A-28 and A-175.
Mutagenesis 28 – 28 D -> A. In P3-D3A mutant; abolished cleavage and activation, leading to prevent thiol protease activity; when associated with A-9 and A-175.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.