Variant position: 324 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 506 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DPGGDGIDWGDDAVA-------LQITV LE-----AGTQAPEGVARGPDALTLL
Mouse DAGADKIDWGDDAAAA------SEITV LE-----TGTEAPE
Rat DAGADKIDWGDNAVA-------SEITV LE-----TGTEAPE
Caenorhabditis elegans ------IDFSAV----------VDLVA DD-----TGA-VGE
Drosophila ESDGGNIDWGIESAPTDAVEINFDIPV EEYGIVVEGTGMDG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 506 CDK5 regulatory subunit-associated protein 3
269 – 506 Required for interaction with UFL1 and mediates interaction with CHEK1
311 – 311 D -> E. Alters cleavage by CASP3 in vitro. Prevents apoptosis-induced cleavage in vivo; when associated with E-268 and E-282.
No reference for the current variant in UniProtKB/Swiss-Prot.
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