Sequence information
Variant position: 223 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 339 The length of the canonical sequence.
Location on the sequence:
AIVFKQYNQTFETHNSTTPL
Q ERSLGLDINMDSRIIHENIV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AIV-----------FKQYN------QTFETHNSTTPLQ ERSLGLDINMDSRIIHENI-----V
Mouse AIV-----------FREYN------QTCENYSSTTSLQ EAS
Rat AIV-----------FNEYD------QTFENYNSTASWR EGS
Bovine AIV-----------FKQYN------QSFETHNCTTSLQ EGS
Chicken DIV-----------FKRYS------QNFQTNY---PLQ ERN
Xenopus tropicalis DIV-----------FKRFN------QPFSSHH---SRP HEK
Baker's yeast TLLGPSRFAESMGPWECYASANFERSPLHDYKKHQGLT GKK
Fission yeast TNVGVNKEANALGAWQIYA------KNLVDRS---PLD TRP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 339
Centromere protein N
Modified residue
226 – 226
Phosphoserine
Modified residue
235 – 235
Phosphoserine
Alternative sequence
205 – 339
Missing. In isoform 2.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.