Variant position: 644 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 657 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EFVENSRKAMKEAGKGGVAD SRELKPMASGASSA
Mouse EFVENSRKAMKEAGKGGAAD ARELKPMLRKR---
Rat EFVENSRKAMKEAGKGGAAD ARKLKPMASGASSA
Xenopus laevis EFVEDSRRALKEP--GSTAE GRELKPMASGTSTA
Baker's yeast SFLNASDLIRKAAERDNMLT T-------------
Fission yeast QLFESNGY------------ --------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 657 Choline transporter-like protein 1
588 – 653 Mitochondrial intermembrane
635 – 657 Disordered
652 – 652 Phosphoserine
Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells.
Wille S.; Szekeres A.; Majdic O.; Prager E.; Staffler G.; Stoeckl J.; Kunthalert D.; Prieschl E.E.; Baumruker T.; Burtscher H.; Zlabinger G.J.; Knapp W.; Stockinger H.;
J. Immunol. 167:5795-5804(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); TISSUE SPECIFICITY; VARIANT ALA-644;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.