Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 235 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EDRFFCPQCRALQAPDPTRD YFSLMDCNRSFRVDTAKLQHR
Mouse GDEFFCSHCRALQPPDPTRD YFSLMNCNRSFRVDVTKLQHR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 235 Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic
30 – 235 Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
72 – 144 J
58 – 58 Divalent metal cation
61 – 61 Divalent metal cation
58 – 58 C -> S. Abolishes self-interaction and interaction with HSPA9 and the CIA complex but does not alter subcellular localization; when associated with S-41; S-44 and S-61.
61 – 61 C -> S. Abolishes self-interaction and interaction with HSPA9 and the CIA complex but does not alter subcellular localization; when associated with S-41; S-44 and S-58.
73 – 76
No reference for the current variant in UniProtKB/Swiss-Prot.
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