Sequence information
Variant position: 202 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 210 The length of the canonical sequence.
Location on the sequence:
LHELLAAELTKALKTKLDLS
S LAYSGKDA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LHELLAAELTKALKT-KLDLSS LAYSGKDA------
Mouse LHELLARELTKALNT-KLDLSS LAYSGKG
Rat LHELLARELTEALNT-KLDLSS LAYSGKG
Bovine LHELLATELTQALKT-KLDLSA LAYSGKD
Caenorhabditis elegans LDSLLNREFRKILADDRIDFSR HV-----
Drosophila LHELLQQEIPGILKSQSVDFLR LPYCS--
Slime mold LRQLLNSEINTLCKY-DMEI-- -------
Baker's yeast LTDILTEEVEKAISKSQ----- -------
Fission yeast LLGILSSEFSKWFSR-PIEFKK SEDF---
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
42 – 210
Frataxin intermediate form
Chain
56 – 210
Frataxin(56-210)
Chain
78 – 210
Frataxin(78-210)
Chain
81 – 210
Frataxin mature form
Alternative sequence
161 – 210
SGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGKDA -> RLTWLLWLFHP. In isoform 2.
Alternative sequence
161 – 210
SGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGKDA -> RYVVDLSVMTGLGKTGCTPTTACPSMSCWPQSSLKP. In isoform 3.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.