Variant position: 395 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 704 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KATDILPKWLRFIRGVVDSE DIPLNLSRELLQESALIRKLR
Mouse KAADILPKWLRFIRGVVDSE DIPLNLSRELLQESALIRKLR
Rat KATDILPKWLRFVRGVVDSE DIPLNLSRELLQESALIRKLR
Bovine KATNILPTWLRFVRGVVDSE DIPLNLSRELLQESALIRKLQ
Slime mold KANGILPEWMRFVRGVVDSE DIPLNVSREHLQDNGLIQRIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
60 – 704 Heat shock protein 75 kDa, mitochondrial
402 – 402 ATP
A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.
Chen C.-F.; Chen Y.; Dai K.; Chen P.-L.; Riley D.J.; Lee W.-H.;
Mol. Cell. Biol. 16:4691-4699(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-704; VARIANT GLU-395;
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