Sequence information
Variant position: 107 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 427 The length of the canonical sequence.
Location on the sequence:
KEGLRLAEDRSKDPHDPHKI
Y EFVNSGVGDFSQPDTSPDTN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KEGLRLAEDRSKDPHDPHKIY EFVNSGV------------------------GDFSQPDTSPDTN
Mouse KEVLRLAADNSKDPYDPHKVY EFVTPGA-------------
Pig KEALRLAEDHSKDPHDPHKIY EFVTSGV-------------
Bovine KEVLRLAEDHSKDSQDPHKIY EFVNSGV-------------
Chicken THMFMLLEDRSKCNDDPHKVY A-VASGVPNDRGSGGPVAGA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 427
Interferon regulatory factor 3
DNA binding
5 – 111
IRF tryptophan pentad repeat
Region
91 – 136
Disordered
Modified residue
97 – 97
Phosphoserine
Modified residue
123 – 123
Phosphoserine
Alternative sequence
1 – 146
Missing. In isoform 3.
Alternative sequence
105 – 427
Missing. In isoform 5.
Mutagenesis
116 – 116
D -> A. Does not affect cleavage by CASP3.
Beta strand
104 – 109
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.