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UniProtKB/Swiss-Prot Q14653: Variant p.Tyr107Phe

Interferon regulatory factor 3
Gene: IRF3
Variant information

Variant position:  107
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Tyrosine (Y) to Phenylalanine (F) at position 107 (Y107F, p.Tyr107Phe).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are large size and aromatic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  107
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  427
The length of the canonical sequence.

Location on the sequence:   KEGLRLAEDRSKDPHDPHKI  Y EFVNSGVGDFSQPDTSPDTN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         KEGLRLAEDRSKDPHDPHKIYEFVNSGV------------------------GDFSQPDTSPDTN

Mouse                         KEVLRLAADNSKDPYDPHKVYEFVTPGA-------------

Pig                           KEALRLAEDHSKDPHDPHKIYEFVTSGV-------------

Bovine                        KEVLRLAEDHSKDSQDPHKIYEFVNSGV-------------

Chicken                       THMFMLLEDRSKCNDDPHKVYA-VASGVPNDRGSGGPVAGA

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 427 Interferon regulatory factor 3
DNA binding 5 – 111 IRF tryptophan pentad repeat
Region 91 – 136 Disordered
Modified residue 97 – 97 Phosphoserine
Modified residue 123 – 123 Phosphoserine
Alternative sequence 1 – 146 Missing. In isoform 3.
Alternative sequence 105 – 427 Missing. In isoform 5.
Mutagenesis 116 – 116 D -> A. Does not affect cleavage by CASP3.
Beta strand 104 – 109


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.