Variant position: 2328 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2347 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EPHADKDFCQEKQVAYCPSG KPEGLNYACLTHSGYGDGSD
Mouse QPQADKDFCQEPQVAYGSPG LSEGLNYACLAHSEHGDVSE
Rat QP-ADKDFCQQPQVAYGSPG HSEGLNYACLAHSGHGDVSE
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Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 2347 Proto-oncogene tyrosine-protein kinase ROS
1883 – 2347 Cytoplasmic
2334 – 2334 Phosphotyrosine; by autocatalysis
2334 – 2334 Y -> F. Loss of phosphorylation at Y-2334 and loss of interaction with PTPN11.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.