Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q16620: Variant p.Gly545Val

BDNF/NT-3 growth factors receptor
Gene: NTRK2
Feedback?
Variant information Variant position: help 545
Type of variant: help LB/B
Residue change: help From Glycine (G) to Valine (V) at position 545 (G545V, p.Gly545Val).
Physico-chemical properties: help Change from glycine (G) to medium size and hydrophobic (V)
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 545
Protein sequence length: help 822
Location on the sequence: help KPDTFVQHIKRHNIVLKREL G EGAFGKVFLAECYNLCPEQD
Residue conservation: help 
Human                         KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD

Mouse                         KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD

Rat                           KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD

Chicken                       KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 32 – 822 BDNF/NT-3 growth factors receptor
Topological domain 455 – 822 Cytoplasmic
Domain 538 – 807 Protein kinase
Binding site 544 – 552
Alternative sequence 478 – 822 Missing. In isoform TrkB-T1 and isoform TrkB-N-T1.
Alternative sequence 538 – 822 Missing. In isoform TrkB-T-Shc and isoform 5.
Beta strand 538 – 545



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.