Sequence information
Variant position: 833 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 913 The length of the canonical sequence.
Location on the sequence:
ECILMGKFTTASDVWAFGVT
L WEVLMLCRAQPFGQLTDEQV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ECILMGKFTTASDVWAFGVTL WEVLMLCRAQPFGQLTDEQV
Chimpanzee ECILMGKFTTASDVWAFGVTL WEVLMLCRAQPFGQLTDEQV
Mouse ECILMGKFTTASDVWAFGVTL WEVLMLCRSQPFGQLTDEQV
Rat ECILMGKFTTASDVWAFGVTL WEVLMLCRSQPFGQLTDEQV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
19 – 913
Epithelial discoidin domain-containing receptor 1
Topological domain
439 – 913
Cytoplasmic
Domain
610 – 905
Protein kinase
Alternative sequence
244 – 913
Missing. In isoform 3.
Helix
822 – 837
Literature citations
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.
Johnson J.D.; Edman J.C.; Rutter W.J.;
Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT VAL-833;
Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.
Sakuma S.; Tada M.; Saya H.; Sawamura Y.; Shinohe Y.; Abe H.;
FEBS Lett. 398:165-169(1996)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT VAL-833;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.