Variant position: 833 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 913 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ECILMGKFTTASDVWAFGVT LWEVLMLCRAQPFGQLTDEQV
Chimpanzee ECILMGKFTTASDVWAFGVT LWEVLMLCRAQPFGQLTDEQV
Mouse ECILMGKFTTASDVWAFGVT LWEVLMLCRSQPFGQLTDEQV
Rat ECILMGKFTTASDVWAFGVT LWEVLMLCRSQPFGQLTDEQV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
19 – 913 Epithelial discoidin domain-containing receptor 1
439 – 913 Cytoplasmic
610 – 905 Protein kinase
244 – 913 Missing. In isoform 3.
822 – 837
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.
Johnson J.D.; Edman J.C.; Rutter W.J.;
Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT VAL-833;
Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.
Sakuma S.; Tada M.; Saya H.; Sawamura Y.; Shinohe Y.; Abe H.;
FEBS Lett. 398:165-169(1996)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT VAL-833;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.