Sequence information
Variant position: 279 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 972 The length of the canonical sequence.
Location on the sequence:
KVLTLNLDQVDFQHAGNYSC
V ASNVQGKHSTSMFFRVVESA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KVLTLNLDQVDFQHAGNYSCV ASNVQGKHSTSMFFRVVESA
Mouse KVRALSLNAVDFQDAGIYSCV ASNDVGTRTATMNFQVVESA
Rat KVRALSLNAVDFQDAGIYSCV ASNDVGTRTATMNFQVVESA
Cat KVLTLNLDHVSFQDAGNYSCT ATNAWGNHSASMVFRVVESA
Zebrafish IESILTIPSVQLSHTGNITCT GQNEAGANSSTTQLLVVEEP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
20 – 972
Macrophage colony-stimulating factor 1 receptor
Topological domain
20 – 517
Extracellular
Domain
203 – 290
Ig-like C2-type 3
Glycosylation
275 – 275
N-linked (GlcNAc...) asparagine
Beta strand
274 – 282
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.