Sequence information
Variant position: 213 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 770 The length of the canonical sequence.
Location on the sequence:
DGSDEGNCSAPASEPPGSLC
P GGTFPCSGARSTRCLPVERR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGSDEGNCSAPASEPPGSLCP GGTFPCSGARSTRCLPVERR
Rat DGSDEGNCSAPASEPPGSLCP GGTFPCSGARSTRCLPVERR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
37 – 770
Low-density lipoprotein receptor-related protein 3
Topological domain
37 – 496
Extracellular
Domain
211 – 250
LDL-receptor class A 2
Glycosylation
199 – 199
N-linked (GlcNAc...) asparagine
Disulfide bond
212 – 227
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.