Variant position: 1275 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1621 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ALGKVESEQEELGSGEIPEG PQEEGEESREESEEDELGETL
Mouse ALGRVEDE-PEFGRGEIPEG LQ-DWEEGREDSEADELGETL
Rat ALERVENE-PEFGLGEIPEG LQ-DWEEGREESEADDLGETL
Zebrafish LAAATPNEQPLTFTNEVSKA ---DYVSDNNDVPEEVLSEE-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments.
Dahlstrand J.; McKay R.D.G.; Zimmerman L.B.; Lendahl U.;
J. Cell Sci. 103:589-597(1992)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASN-1016; LEU-1101 AND LEU-1275;
A quantitative atlas of mitotic phosphorylation.
Dephoure N.; Zhou C.; Villen J.; Beausoleil S.A.; Bakalarski C.E.; Elledge S.J.; Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311; THR-315; SER-325; THR-388; SER-398; SER-471; SER-548; SER-564; SER-578; SER-588; SER-746; SER-768; THR-851; SER-905 AND SER-1418; VARIANT [LARGE SCALE ANALYSIS] LEU-1275; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Rigbolt K.T.; Prokhorova T.A.; Akimov V.; Henningsen J.; Johansen P.T.; Kratchmarova I.; Kassem M.; Mann M.; Olsen J.V.; Blagoev B.;
Sci. Signal. 4:RS3-RS3(2011)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325; SER-355; SER-358; SER-548; SER-578; SER-680; SER-746; SER-768; SER-790; SER-820; SER-831; SER-894; SER-905; SER-913; SER-934; SER-1261; SER-1282; SER-1286; SER-1347; SER-1418; SER-1452; SER-1496; SER-1498; SER-1577; SER-1617 AND SER-1618; VARIANT [LARGE SCALE ANALYSIS] LEU-1275; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
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