Variant position: 331 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 364 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QKKSKLHGPTETSSCSGAAP TVEMDEELHYASLNFHG-------------MNPS
Mouse TAILRIQDPYRRTHLRNRAV ST-----LRFPWISWEGSLRS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 364 Myeloid cell surface antigen CD33
283 – 364 Cytoplasmic
340 – 340 Phosphotyrosine; by LCK
309 – 364 KHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSEVRTQ -> VR. In isoform 3.
340 – 340 Y -> A. Abolishes binding to PTPN6 and PTPN11. Increases binding of red blood cells.
340 – 340 Y -> F. Complete loss of phosphorylation by LCK.
No reference for the current variant in UniProtKB/Swiss-Prot.
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