Variant position: 280 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 469 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SHGHGRQERSTKEKQSSEEE EKETRGVQKRRGGSTVPKDGP
Mouse SHTHGDRHECSSKEKPSTEE EKEVGGLRKRRGGNTGPRDGP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 469 Zinc transporter SLC39A7
242 – 310 Disordered
260 – 288 Basic and acidic residues
275 – 275 Phosphoserine; by CK2
276 – 276 Phosphoserine; by CK2
275 – 275 S -> A. Loss of phosphorylation in response to Zn(2+) treatment and of cytosolic Zn(2+) release; when associated with A-276.
276 – 276 S -> A. Loss of phosphorylation in response to Zn(2+) treatment and of cytosolic Zn(2+) release; when associated with A-275.
cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.
Ando A.; Kikuti Y.Y.; Shigenari A.; Kawata H.; Okamoto N.; Shiina T.; Chen L.; Ikemura T.; Abe K.; Kimura M.; Inoko H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLY-280;
Molecular cloning and characterization of the human KE4 gene and 5' flanking region.
Vergara A.; Lana I.; Corella A.; de Miguel C.; Migliaccio M.; Encio I.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLY-280;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.