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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q53G59: Variant p.Pro72Leu

Kelch-like protein 12
Gene: KLHL12
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Variant information Variant position: help 72
Type of variant: help LB/B
Residue change: help From Proline (P) to Leucine (L) at position 72 (P72L, p.Pro72Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 72
Protein sequence length: help 568
Location on the sequence: help AACSDYFCAMFTSELSEKGK P YVDIQGLTASTMEILLDFVY
Residue conservation: help 
Human                         AACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVY

Mouse                         AACSDYFCAMFTSELSEKGKPYVDIQGLTAATMEILLDFVY

Rat                           AACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVY

Bovine                        AACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVY

Xenopus laevis                AACSDYFCAMFTNELSEKGKPYVDIQGLTSSTMEILLDFVY

Zebrafish                     AACSDYFCAMFTSELAEKGKSFVDIQGLTASTMEILLDFVY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 568 Kelch-like protein 12
Domain 33 – 100 BTB
Mutagenesis 60 – 60 A -> EK. Abolished ubiquitination by the SCF(FBXL17) complex.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.