Variant position: 269 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 467 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SRQSLPIKAILKSLPVWAIS---- TGSFTFFWSHNIMTL--YTPMFI
Mouse GRQSLPIKAMLKSLPLWAII---- LNSFAFIWSNSLLVT--
Rat GRQSLPIKAMLKSLPLWAII---- LNSFAFIWSNNLLVT--
Rabbit TRQSLPIKAMIKSLPLWAIS---- FCCFAYLWTYSRLIV--
Baker's yeast RRRSLKAQDLIMQGIMKAVNGNPD RNKSLLLGTSNILFAKK
Fission yeast RRRDPHTQEIVLQGLMKAQEDF-- KGPGSFLGTSNVYFAAK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 467 Sodium-dependent phosphate transport protein 1
257 – 277 Helical
246 – 299 Missing. In isoform 2.
Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.
Chong S.S.; Kristjansson K.; Zoghbi H.Y.; Hughes M.R.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ILE-269;
Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression.
Miyamoto K.; Tatsumi S.; Sonoda T.; Yamamoto H.; Minami H.; Taketani Y.; Takeda E.;
Biochem. J. 305:81-85(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-467 (ISOFORM 1); VARIANT ILE-269;
Expression of a human NPT1/SLC17A1 missense variant which increases urate export.
Sakiyama M.; Matsuo H.; Nagamori S.; Ling W.; Kawamura Y.; Nakayama A.; Higashino T.; Chiba T.; Ichida K.; Kanai Y.; Shinomiya N.;
Nucleosides Nucleotides Nucleic Acids 35:536-542(2016)
Cited for: VARIANT ILE-269; CHARACTERIZATION OF VARIANT ILE-269; SUBCELLULAR LOCATION; FUNCTION;
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