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UniProtKB/Swiss-Prot Q13241: Variant p.Ser25Ala

Natural killer cells antigen CD94
Gene: KLRD1
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Variant information Variant position: help 25
Type of variant: help LB/B
Residue change: help From Serine (S) to Alanine (A) at position 25 (S25A, p.Ser25Ala).
Physico-chemical properties: help Change from small size and polar (S) to small size and hydrophobic (A)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 25
Protein sequence length: help 179
Location on the sequence: help KTTLWRLISGTLGIICLSLM S TLGILLKNSFTKLSIEPAFT
Residue conservation: help 
Human                         KTTLWRLISGTLGIICLSLMSTLGILLKNSFTKLSIEPAFT

                              QTTLWNLISGILGVICLLLMTTMGILLKNLLLTESIQPTLS

Rhesus macaque                KTTLWRLISGTLGIICLSLMATLGILLKNSFTKLSVEPAYT

Chimpanzee                    KTTLWRLISGTLGIICLSLMATLGILLKNSFTKLSIEPAFT

Mouse                         RITRWRLMSVIFGIKCLFLMVTLGVLLINSFTIQNIQSTPS

Rat                           RITRWRLMSMFFGIKCLFLIVALGVLVKNSFTIQNIQSTPS

Bovine                        RTTAWRLISGVLGVICLVLMAALGVLLKNSLTKRSVQ----
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 179 Natural killer cells antigen CD94
Transmembrane 11 – 31 Helical; Signal-anchor for type II membrane protein
Alternative sequence 1 – 34 MAVFKTTLWRLISGTLGIICLSLMSTLGILLKNS -> MAA. In isoform 3.



Literature citations
Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.
Chang C.; Rodriguez A.; Carretero M.; Lopez-Botet M.; Phillips J.H.; Lanier L.L.;
Eur. J. Immunol. 25:2433-2437(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ALA-25; Structure of the human CD94 C-type lectin gene.
Rodriguez A.; Carretero M.; Glienke J.; Bellon T.; Ramirez A.; Lehrach H.; Francis F.; Lopez-Botet M.;
Immunogenetics 47:305-309(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ALA-25; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ALA-25;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.