Variant position: 25 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 179 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KTTLWRLISGTLGIICLSLM STLGILLKNSFTKLSIEPAFT
Rhesus macaque KTTLWRLISGTLGIICLSLM ATLGILLKNSFTKLSVEPAYT
Chimpanzee KTTLWRLISGTLGIICLSLM ATLGILLKNSFTKLSIEPAFT
Mouse RITRWRLMSVIFGIKCLFLM VTLGVLLINSFTIQNIQSTPS
Rat RITRWRLMSMFFGIKCLFLI VALGVLVKNSFTIQNIQSTPS
Bovine RTTAWRLISGVLGVICLVLM AALGVLLKNSLTKRSVQ----
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 179 Natural killer cells antigen CD94
11 – 31 Helical; Signal-anchor for type II membrane protein
1 – 34 MAVFKTTLWRLISGTLGIICLSLMSTLGILLKNS -> MAA. In isoform 3.
Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.
Chang C.; Rodriguez A.; Carretero M.; Lopez-Botet M.; Phillips J.H.; Lanier L.L.;
Eur. J. Immunol. 25:2433-2437(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ALA-25;
Structure of the human CD94 C-type lectin gene.
Rodriguez A.; Carretero M.; Glienke J.; Bellon T.; Ramirez A.; Lehrach H.; Francis F.; Lopez-Botet M.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ALA-25;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ALA-25;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.