Variant position: 164 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 399 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AAVGELPEKSKLQEIYQELT RLKAAVGELPEKSKLQEIYQE
Gorilla AAVGELPEKSKLQEIYQELT QLKAAVGELPEKSKLQEIYQE
Chimpanzee AAVGELPEKSKLQEIYQELT QLKAAVGELPEKSKLQEIYQE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 399 C-type lectin domain family 4 member M
71 – 399 Extracellular
154 – 176 3
108 – 269 7 X approximate tandem repeats
147 – 261 Missing. In isoform 7.
Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.
Mummidi S.; Catano G.; Lam L.; Hoefle A.; Telles V.; Begum K.; Jimenez F.; Ahuja S.S.; Ahuja S.K.;
J. Biol. Chem. 276:33196-33212(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4; 5; 6 AND 7); ALTERNATIVE SPLICING (ISOFORM 3); POLYMORPHISM; VARIANT GLN-164;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.