Variant position: 341 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 840 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DSCVPGDTVTITGIVKVSNA EEG-SRNKNDKCMFLLYIEANS
Mouse DSCVPGDTVTVTGIVKVSNS EEG-SRNKNDKCMFLLYIEAN
Rat DSCVPGDTVTVTGIVKVSNS EEG-SRSKNDKCMFLLYIEAN
Bovine DSCVPGDTVTITGVVKVSNA EE-----------------AN
Chicken DSCVPGDVVTITGVVKVSST EEGASKNKNDKCVFLLYIEAN
Xenopus laevis DSCVPGDMITVTGIVKVSNT RDGGFKNKNNKCMFLLYIEAN
Xenopus tropicalis DSCVPGDMVTVTGIVKVSNT RDGGFKNKNNKCMFLLYIEAN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 840 DNA helicase MCM8
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
Lee K.Y.; Im J.S.; Shibata E.; Park J.; Handa N.; Kowalczykowski S.C.; Dutta A.;
Nat. Commun. 6:7744-7744(2015)
Cited for: FUNCTION; CATALYTIC ACTIVITY; INTERACTION WITH THE MRN COMPLEX; SUBCELLULAR LOCATION; MUTAGENESIS OF PRO-456; CHARACTERIZATION OF VARIANT LYS-341;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.