UniProtKB/Swiss-Prot P10451: Variant p.Ser224Asn

Gene: SPP1
Chromosomal location: 4q21-q25
Variant information

Variant position:  224
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Serine (S) to Asparagine (N) at position 224 (S224N, p.Ser224Asn).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and polar (S) to medium size and polar (N)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.

Sequence information

Variant position:  224
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  314
The length of the canonical sequence.

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.





Bovine                        ----------------------KTSQLTDHSKETNSSELSK


Sheep                         ----------------------KTSQLTDHSEETNSDELPK

Chicken                       -------------WLPKESREQDSRELAQHQ-SVENDSRPR

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

Chain 17 – 314 Osteopontin
Modified residue 215 – 215 Phosphoserine; by FAM20C
Modified residue 219 – 219 Phosphoserine; by FAM20C
Modified residue 224 – 224 Phosphoserine; by FAM20C
Modified residue 225 – 225 Phosphotyrosine
Modified residue 228 – 228 Phosphoserine; by FAM20C
Modified residue 234 – 234 Phosphoserine; by FAM20C
Modified residue 237 – 237 Phosphothreonine; by FAM20C
Modified residue 239 – 239 Phosphoserine; by FAM20C
Modified residue 243 – 243 Phosphoserine; by FAM20C

Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.