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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P10451: Variant p.Ser224Asn

Osteopontin
Gene: SPP1
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Variant information Variant position: help 224 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Asparagine (N) at position 224 (S224N, p.Ser224Asn). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (N) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 224 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 314 The length of the canonical sequence.
Location on the sequence: help AIPVAQDLNAPSDWDSRGKD S YETSQLDDQSAETHSHKQSR The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         AIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSR

Mouse                         VIPVAQLLSMPSDQDNNGKGSHESSQLDEPSLETHRLEHSK

Rat                           VIPVAQRLSVPSDQDSNGKTSHESSQLDEPSVETHSLEQSK

Pig                           AILVAQRLHVASDLDSQEKDSQETSQPDDRSVETRSQEQSK

Bovine                        ----------------------KTSQLTDHSKETNSSELSK

Rabbit                        AIPVAQHLNVPSDWDSQEKDSHDVSQVDDHSVETQSHEQAR

Sheep                         ----------------------KTSQLTDHSEETNSDELPK

Chicken                       -------------WLPKESREQDSRELAQHQ-SVENDSRPR

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 17 – 314 Osteopontin
Region 41 – 290 Disordered
Compositional bias 216 – 290 Basic and acidic residues
Modified residue 215 – 215 Phosphoserine; by FAM20C
Modified residue 219 – 219 Phosphoserine; by FAM20C
Modified residue 224 – 224 Phosphoserine; by FAM20C
Modified residue 225 – 225 Phosphotyrosine
Modified residue 228 – 228 Phosphoserine; by FAM20C
Modified residue 234 – 234 Phosphoserine; by FAM20C
Modified residue 237 – 237 Phosphothreonine; by FAM20C
Modified residue 239 – 239 Phosphoserine; by FAM20C
Modified residue 243 – 243 Phosphoserine; by FAM20C
Glycosylation 234 – 234 O-linked (Xyl...) (chondroitin sulfate) serine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.