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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P09874: Variant p.Pro377Ser

Poly [ADP-ribose] polymerase 1
Gene: PARP1
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Variant information Variant position: help 377
Type of variant: help LB/B
Residue change: help From Proline (P) to Serine (S) at position 377 (P377S, p.Pro377Ser).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 377
Protein sequence length: help 1014
Location on the sequence: help FPPETSASVAATPPPSTASA P AAVNSSASADKPLSNMKILT
Residue conservation: help 
Human                         FPPETSASVAATPPPSTASAPAAVNSS------ASADKPLSNMKILT

Mouse                         FPPESSAPITVHWPLSVTSAPTAVNSS------APADKPLS

Rat                           FPPESSAPAPPAPPVSITSAPTAVNSS------APADKPLS

Bovine                        FPPESSTPVGAAAPPSAASAPAAVHS-------GPPDKPLS

Chicken                       FPPEAATVNSAPPPP--ASAPLTETVT------APQDKPLT

Zebrafish                     FPKDAPPAAATPSSGSTTSAATSVSSASKNLTEAPADKPLT

Caenorhabditis elegans        F----------------------------------------
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 1014 Poly [ADP-ribose] polymerase 1
Chain 215 – 1014 Poly [ADP-ribose] polymerase 1, processed C-terminus
Region 361 – 385 Disordered
Region 373 – 524 Automodification domain
Modified residue 364 – 364 Phosphoserine
Modified residue 368 – 368 Phosphothreonine
Modified residue 387 – 387 PolyADP-ribosyl aspartic acid
Mutagenesis 357 – 357 F -> Y. Does not affect auto-poly-ADP-ribosylation.
Mutagenesis 394 – 394 K -> Q. Strongly decreased ability of the BRCT domain to bind intact DNA; when associated with Q-418.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.