Variant position: 12 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 434 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEVRPKESWNH ADFVHCEDTESVPGKPSVNAD
Rhesus macaque MEVRPKEGWNH ADFVYCEDTEFAPGKPTVNAD
Mouse --MRPEESWSR VGLVQCEEADSALEEP-INVE
Rat --MRPEERWNH VGLVQREEADSVLEEP-INVD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 434 Nuclear receptor subfamily 1 group I member 2
1 – 55 Missing. In isoform 1B and isoform 2B.
1 – 1 M -> MDPRGEVGAKNLPPNSPRGPEANL. In isoform 1C and isoform 2C.
1 – 1 M -> MTVTRTHHFKEGSLRAPAIPLHSAAAELASNHPRGPEANL. In isoform 3.
Identification of a novel protein isoform of the human nuclear hormone receptor PXR/SXR and localization to chromosome 3q12.1 -13.3.
Heard D.J.; Holloway J.; Hansen C.; Tommerup N.; Aagaard L.; Vissing H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 2A; 2B AND 2C); VARIANT THR-12;
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