Variant position: 126 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 265 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GEHTVGEQPSGEQPSGEHLS GEQPLSELESGEQPSDEQPSG
Mouse SEHTSEEHSSGEHTSTEHTS GEQPATEQSSSDQPS-EASSG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 265 Acrosomal protein SP-10
125 – 129 3-3
85 – 168 4 X 4 AA repeats of S-G-E-H
110 – 174 9 X 5 AA repeats of [SV]-G-E-Q-[PSA]
41 – 224 Missing. In isoform 11.
41 – 184 Missing. In isoform 10.
41 – 135 Missing. In isoform 6.
111 – 155 Missing. In isoform 7.
121 – 165 Missing. In isoform 9.
Cloning and characterization of the gene coding for the human acrosomal protein SP-10.
Wright R.M.; Suri A.K.; Kornreich B.; Flickinger C.J.; Herr J.C.;
Biol. Reprod. 49:316-325(1993)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ARG-126;
Suzuki Y.; Sugano S.; Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ARG-126;
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