Variant position: 341 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 375 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VDNLTLDGNPFLVPGTALPH EGSMNSGVVPACARSTLSVGV
Mouse VGNLSLKGNPFLD---SESH SEKFNSGVVTAGAPSSQAVAL
Rat VGSLSLTGNPFLH---SESQ SEAYNSGVVIATALSPGSAGL
Bovine VNDLTLDGNPFLDPGALQHQ NDPMISGVVPACARSALTMGV
Rabbit VVNLSLDGNPFLVPGASKLQ EDLTNSGVFPACPPSPLAMGM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 367 Monocyte differentiation antigen CD14, urinary form
20 – 345 Monocyte differentiation antigen CD14, membrane-bound form
322 – 349 LRR 11
290 – 375 Required for response to bacterial lipopolysaccharide (LPS)
345 – 345 GPI-anchor amidated asparagine
323 – 323 N-linked (GlcNAc...) asparagine
336 – 336 O-linked (GalNAc...) threonine
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.