Sequence information
Variant position: 329 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 456 The length of the canonical sequence.
Location on the sequence:
SLVVADFGCGDCRLASSIRN
P VHCFDLASLDPRVTVCDMAQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLVVADFGCGDCRLA-----------------SSIRNP VHCFDLASLDPRVTVCDMAQ
Mouse SLVVADFGCGDCRLA-----------------SSVRNP VHC
Rat SLVVADFGCGDCRLA-----------------SSVRNP VHC
Caenorhabditis elegans QQSVFDLGCGEAKIA---------------EAVGEKHK IRS
Drosophila TAIIGDFGCGEGKLA-----------------QSVPNK VYS
Slime mold RKRIADLGCGEAKLA---------------ERLQHKHT IQS
Baker's yeast EIVIADMGCGEAQLALEINNFFKNYNKKAKKYLKRRHK VHS
Fission yeast NIVIADLGCGEAKIA-------------STFRKSRSLQ VHS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 456
Ribosomal RNA-processing protein 8
Binding site
316 – 316
S-adenosyl-L-methionine; via carbonyl oxygen
Binding site
334 – 334
S-adenosyl-L-methionine
Binding site
346 – 346
S-adenosyl-L-methionine
Binding site
347 – 347
S-adenosyl-L-methionine
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.