Variant position: 223 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 662 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NLSRNSLTCISDFSLQQLRV LDLSCNSIEAFQTASQPQAEF
Mouse NLSRNSLTCISDFSLQQLQV LDLSCNSIEAFQTAPEPQAQF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 662 Transforming growth factor beta activator LRRC32
20 – 627 Extracellular
220 – 240 LRR 8
203 – 203 N-linked (GlcNAc...) asparagine
211 – 211 Interchain (with C-33 in TGFB1); in linked form
211 – 211 C -> A. Abolishes interaction with Latency-associated peptide (LAP) of TGFB1; when associated with A-350.
222 – 224
No reference for the current variant in UniProtKB/Swiss-Prot.
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