Variant position: 295 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 691 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KDRDRRRVKNGEHSWDLDRE KNREHDKPEKKSASSGEMSKK
Mouse RDRERRKSKNGEHTRDPDRE KSRDADKPEKKSSSSGEISRK
Rat KDRERRKSKNGEHTRDPDRE KSRDADKSEKK----------
Zebrafish REKRREKEKDKERPRETE-E KLKDRGDRKIKAAEEISKSKP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 691 TRAF3-interacting protein 1
1 – 323 Abolishes microtubules-binding when missing
136 – 508 Disordered
223 – 691 DISC1-interaction domain
149 – 332 Basic and acidic residues
No reference for the current variant in UniProtKB/Swiss-Prot.
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