Variant position: 410 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 583 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LGATLPVGQPVGGDPEVRKQ MPP-------PPPC---PGRE-LFDDPSYVNV
Mouse LGATLPIGQHAAGDHEVRKQ MLP-------PPPC---PGRE
Rat LGATLPIGQHVTGDHEVRKQ MLP-------PPPC---PGRE
Bovine LGATLPVGQPAGGDPEARRQ MPP-------PPPS---SGRE
Xenopus laevis MGATLPVGQVSGAEQDSRKM QPTLQGRERFPVPCSRPPNRP
Baker's yeast SFSVDSLKEYLVNDAKVILK KLS-------AVGY---PDAQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 583 SHC-transforming protein 1
340 – 487 CH1
427 – 427 Phosphotyrosine
417 – 417 P -> PA. In isoform 7 and isoform 6.
427 – 427 Y -> F. No effect on interaction with GRB2; isoform p52Shc (in vitro).
No reference for the current variant in UniProtKB/Swiss-Prot.
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