Variant position: 292 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 425 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EFRDNPGNFVKTEETLFEIQ GIDPIASAIQNLKTTDKTKPS
Mouse EVRDNPGNFVKTEETLFEIQ GIDPITSAIQNLKTTDKTNPS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 425 TRAF family member-associated NF-kappa-B activator
291 – 292 (Microbial infection) Cleavage; by viral Seneca Valley virus protease 3C
291 – 291 Cleavage by EMCV protease 3C
118 – 425 Missing. In isoform Short.
120 – 425 Missing. In isoform 3.
272 – 272 E -> A. Complete loss of cleavage by Seneca Valley virus protease 3C.
291 – 291 Q -> A. Complete loss of cleavage by Seneca Valley virus protease 3C.
No reference for the current variant in UniProtKB/Swiss-Prot.
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