Variant position: 75 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 712 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TEARISLEALKADAVARLVA RQWAGVDSTEDPEEPPDVSWA
Mouse TEARVSLESLKMNTVAQLVA HQWADMETTEGPEEPPDLSWT
Bovine TEARISLEALKADAVAQLVA RQWAGVDSTETPEEPPDLSWA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 712 TIR domain-containing adapter molecule 1
1 – 153 TRIF-NTD
88 – 88 E -> A. Reduces binding to TRAF6 and activation of NFKB signaling pathway; when associated with A-252 and A-303.
68 – 76
No reference for the current variant in UniProtKB/Swiss-Prot.
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