Variant position: 166 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 362 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DVIFLQEVIPPYYSYLKKRS SNYEIITGHEE-GYFTAIMLKK
Mouse DVVFLQEVIPPYCAYLKKRA ASYTIITGNEE-GYFTAILLK
Rat DVVFLQEVIPSYCAYLRKRA RTYNIITGNEE-GYFTAILLK
Bovine DVIFLQEVIPPYYAYLKKKA SSYKIITGREE-GYFTAIMLK
Chicken DVVFLQEVIPPYLCILQRRA GGYTIIPGNVD-GYFTAMLLK
Xenopus laevis DVVFLQEVIPPYCEYLKKRA VSYKIITGNED-EYFTAMMLK
Xenopus tropicalis DVVFLQEVIPPYYEYLKKRA VSYTIITGNED-EYFTAMMLK
Zebrafish DVVFLQELIPAYVQYLKKRA VSYLFFEGSDD-GYFTGIMLR
Caenorhabditis elegans DILFLQEVVDRDLAPIDKLQ SLYKIYYSNKGCQYYTAILVS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 362 Tyrosyl-DNA phosphodiesterase 2
152 – 152 Magnesium
178 – 178 Interaction with 5' end of substrate DNA
152 – 152 E -> A. Loss of phosphodiesterase activity.
178 – 178 Y -> FW. Strongly decreased phosphodiesterase activity.
No reference for the current variant in UniProtKB/Swiss-Prot.
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