Variant position: 378 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1507 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FYIDLKQTNDVLLTFEALKH LASLLLHNKFATEFVAHGGVQ
Mouse FYIDLKQTNDVLLTFEALKH LASLLLHNKFATEFVAHGGVQ
Caenorhabditis elegans DYIDLEKSKDVRLTFDALKY LTSLLVHRKFALEFVNKGGIP
Drosophila GYLENLDRRDTCLAYEVLKY LASLLCHKKFALEFISHGGLE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1507 DDB1- and CUL4-associated factor 1
141 – 500 Protein kinase-like
225 – 673 Missing. In isoform 3.
361 – 361 D -> A. Abolishes serine/threonine-protein kinase kinase activity.
363 – 363 K -> A. Abolishes serine/threonine-protein kinase kinase activity.
VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.
Kim K.; Kim J.M.; Kim J.S.; Choi J.; Lee Y.S.; Neamati N.; Song J.S.; Heo K.; An W.;
Mol. Cell 52:459-467(2013)
Cited for: FUNCTION; CATALYTIC ACTIVITY; INDUCTION; MUTAGENESIS OF LYS-194; ASP-361 AND LYS-363; CHARACTERIZATION OF VARIANT PHE-378;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.