Variant position: 481 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 501 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VMAAICALFMLPLCLMVCQW RCLRCLRQQHDDFADDISLLK
Mouse VMAAICALFMLPLCLMVCQW RCLRCLRHQHDDFADDISLLK
Rat VMAAICALFMLPLCLMVCQW RCLRCLRHQHDDFADDISLLK
Bovine VMAAICALFMLPLCLMVCQW RCLRCLRHQHDDFADDISLLK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
46 – 501 Beta-secretase 1
479 – 501 Cytoplasmic
479 – 501 Interaction with RTN3
498 – 498 Phosphoserine
474 – 474 S-palmitoyl cysteine
478 – 478 S-palmitoyl cysteine
482 – 482 S-palmitoyl cysteine
485 – 485 S-palmitoyl cysteine
501 – 501 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
498 – 498 S -> A. No effect on endocytosis from the cell surface. Increases recycling from endosomes to the cell surface.
498 – 498 S -> D. No effect on endocytosis form the cell surface. Decreases recycling from endosomes to the cell surface.
501 – 501 K -> R. Inhibits ubiquitination. No effect on endocytosis rate. Induced protein stability and acculmulation in early and late endosomes, lysosomes and cell membrane. Effects on protein stability and defective internalization increases; when associated with A-499-500-A.
No reference for the current variant in UniProtKB/Swiss-Prot.
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