Sequence information
Variant position: 9 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 219 The length of the canonical sequence.
Location on the sequence:
MLRAGAPT
G DLPRAGEVHTGTTIMAVEFD
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MLRAGAPTG DLPRAGEVHTGTTIMAVEFD
Mouse MLRAGAPTA GSFRTEEVHTGTTIMAVEFD
Rat MLQAGAPTA GSFRTGEVHTGTTIMAVEFD
Bovine MLRTGAPNG DLPRAGEVHTGTTIMAVEFD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Propeptide
1 – 20
Removed in mature form
Active site
21 – 21
Nucleophile
Alternative sequence
4 – 13
Missing. In isoform LMP2.S.
Mutagenesis
20 – 20
G -> A. Impairs correct processing at the consensus site.
Mutagenesis
21 – 21
T -> A. Impairs correct processing at the consensus site.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.