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UniProtKB/Swiss-Prot P09960: Variant p.Tyr131His

Leukotriene A-4 hydrolase
Gene: LTA4H
Variant information

Variant position:  131
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Tyrosine (Y) to Histidine (H) at position 131 (Y131H, p.Tyr131His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and aromatic (Y) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  131
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  611
The length of the canonical sequence.

Location on the sequence:   PKSSALQWLTPEQTSGKEHP  Y LFSQCQAIHCRAILPCQDTP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         PKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTP

Mouse                         PKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTP

Rat                           PKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTP

Bovine                        PKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTP

Slime mold                    VDSNALQWLTKDQTAGKLHPYLFSQCQAIHARSLVPCQDSP

Baker's yeast                 DKCTALQWLNSKQTKGGK-PYVFSQLEAIHARSLFPCFDTP

Fission yeast                 KDCTALQFLKPEQTIGGKFPYVFSECQAIHARSFIPCQDTP

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 611 Leukotriene A-4 hydrolase
Mutagenesis 135 – 135 Q -> AL. Srongly increased epoxide hydrolase activity.
Mutagenesis 135 – 135 Q -> A. Strongly reduced aminopeptidase activity. Strongly decreased affinity for leukotriene. Abolishes epoxide hydrolase activity.
Mutagenesis 137 – 137 Q -> A. No loss of activity.
Mutagenesis 137 – 137 Q -> L. Aminopeptidase activity strongly impaired, but keeps LTA4 activity.
Mutagenesis 137 – 137 Q -> N. Aminopeptidase activity almost absent, but keeps LTA4 activity.
Mutagenesis 140 – 140 H -> Q. Aminopeptidase activity almost absent, but keeps LTA4 activity.
Beta strand 131 – 134


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.