Variant position: 167 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 480 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MNEFEYLKLLGKGTFGKVIL VKEKATGRYYAMKILKKEVIV
Mouse MNEFEYLKLLGKGTFGKVIL VKEKATGRYYAMKILKKEVIV
Rat MNEFEYLKLLGKGTFGKVIL VKEKATGRYYAMKILKKEVIV
Bovine MNDFEYLKLLGKGTFGKVIL VKEKATGRYYAMKILKKEVIV
Xenopus laevis MNEFEYLKLLGKGTFGKVIL VKEKATGRYYAMKILKKEVIV
Caenorhabditis elegans MEDFDFLKVLGKGTFGKVIL CKEKRTQKLYAIKILKKDVII
Drosophila LENFEFLKVLGKGTFGKVIL CREKATAKLYAIKILKKEVII
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 480 RAC-alpha serine/threonine-protein kinase
150 – 408 Protein kinase
161 – 161 Inhibitor; via amide nitrogen
179 – 179 ATP
176 – 176 Phosphotyrosine; by TNK2
176 – 176 Y -> F. Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473.
160 – 169
No reference for the current variant in UniProtKB/Swiss-Prot.
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