Variant position: 196 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 712 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PSSTKPGPESSVSLLQGARP FPFCWPLCEISRGTHNFSEEL
Mouse PSSTKSSPESPVSGLQRAHP SPFCWPFCEISQGTCNFSEEL
Bovine PSSTKPSPESPMSLLPGAPS SSFCWPLHEICQGTHDFSEEL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 712 Interleukin-1 receptor-associated kinase 1
110 – 211 ProST region
209 – 209 Phosphothreonine; by IRAK4
180 – 180 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
209 – 209 T -> A. Completely abolishes auto-phosphorylation in the kinase domain.
195 – 197
IRAK: a kinase associated with the interleukin-1 receptor.
Cao Z.; Henzel W.J.; Gao X.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PARTIAL PROTEIN SEQUENCE; VARIANTS SER-196 AND LEU-532;
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