Variant position: 365 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 649 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VVGASYVALECAGFLAGIGL DVTVMVRSILLRGFDQDMANK
Mouse VVGASYVALECAGFLAGIGL DVTVMVRSILLRGFDQDMANK
Rat VVGASYVALECAGFLAGIGL DVTVMVRSILLRGFDQDMANK
Pig VVGASYVALECAGFLAGIGL DVTVMVRSILLRGFDQDMANK
Bovine VVGASYVALECAGFLAGIGL DVTVMVRSILLRGFDQDMANK
Caenorhabditis elegans CVGASYVSLECAGFLHGFGF DVTVMVRSILLRGFDQDMAER
Drosophila VVGAGYIGLECAGFLKGLGY EPTVMVRSIVLRGFDQQMAEL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 649 Thioredoxin reductase 1, cytoplasmic
Cloning and sequencing of a human thioredoxin reductase.
Gasdaska P.Y.; Gasdaska J.R.; Cochran S.; Powis G.;
FEBS Lett. 373:5-9(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5); PROTEIN SEQUENCE OF 153-161; 307-315 AND 585-607; VARIANT GLY-365;
Evidence for intriguingly complex transcription of human thioredoxin reductase 1.
Rundloef A.-K.; Janard M.; Miranda-Vizuete A.; Arner E.S.;
Free Radic. Biol. Med. 36:641-656(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5); VARIANT GLY-365;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.