Variant position: 679 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 699 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QWYLVGTVSWGDDCGKKDRY GVYSYIHHNKDWIQRVTGVRN
Mouse QWYLVGVVSWGEDCGKKDRY GVYSYIYPNKDWIQRITGVRN
Rat QWYLVGVVSWGEDCGKKDRY GVYSYIYPNKDWIQRVTGVRN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 699 Mannan-binding lectin serine protease 1
449 – 699 Mannan-binding lectin serine protease 1 light chain
449 – 696 Peptidase S1
381 – 699 Missing. In isoform 3.
436 – 699 Missing. In isoform 2 and isoform 4.
677 – 683
No reference for the current variant in UniProtKB/Swiss-Prot.
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