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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O95905: Variant p.Asn501Ser

Protein ecdysoneless homolog
Gene: ECD
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Variant information Variant position: help 501
Type of variant: help LB/B
Residue change: help From Asparagine (N) to Serine (S) at position 501 (N501S, p.Asn501Ser).
Physico-chemical properties: help Change from medium size and polar (N) to small size and polar (S)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 501
Protein sequence length: help 644
Location on the sequence: help ITFDADSFLNYFDKILGPRP N ESDSDDLDDEDFECLDSDDD
Residue conservation: help
Human                         ITFDAD-----------SFLNYFDKILGPRP--NESDSDDLD-DEDFECLDSDDD

Mouse                         ITFDAD-----------SFLNYFDKILGAKP--QESDSEDD

Drosophila                    PQANGSTGLTAKVKKNPSMRKACQRNSVIQP--EEPDSTHV

Slime mold                    YGNGGDDNISFDSNKFMDILKGFTDNNKYDDDYDDDDDDDD

Fission yeast                 YGVKNS-----------------DTDTDSDSLADSDDEIFL

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 644 Protein ecdysoneless homolog
Region 439 – 644 Transcription activation
Region 496 – 537 Disordered
Modified residue 503 – 503 Phosphoserine
Modified residue 505 – 505 Phosphoserine
Modified residue 518 – 518 Phosphoserine
Mutagenesis 481 – 481 I -> A. Decreases transactivation activity.
Mutagenesis 484 – 484 D -> F. Decreases transactivation activity.
Mutagenesis 489 – 489 L -> A. Decreases transactivation activity.
Mutagenesis 503 – 503 S -> A. Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-505, A-518, A-572, A-579 and A-584.
Mutagenesis 505 – 505 S -> A. Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-518, A-572, A-579 and A-584.
Mutagenesis 510 – 510 D -> R. Increases transactivation activity.
Mutagenesis 512 – 512 D -> R. Increases transactivation activity.
Mutagenesis 518 – 518 S -> A. Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-505, A-572, A-579 and A-584.
Mutagenesis 520 – 520 D -> P. Increases transactivation activity.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.