Sequence information
Variant position: 170 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 425 The length of the canonical sequence.
Location on the sequence:
FPPLDDYSHSIPENTNFPAG
I EPQSNIPETPPPGYLSEDGE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FPPLDDYSHSIPENTNFPAGI EPQSN-IPETPPPGYLSEDGE
Mouse FPPLDDYSHSIPENTNFPAGI EPQSN-IPETPPPGYLSEDG
Rat FPPLDDYSHSIPENTNFPAGI EPQSN-IPETPPPGYLSEDG
Pig FPPLDDYSHSIPENTNFPAGI EPQSN-IPETPPPGYLSEDG
Chicken FPPLDDYSHSIPENTNFPAGI EPQSNYIPETPPPGYLSEDG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 425
Mothers against decapentaplegic homolog 3
Region
137 – 231
Linker
Region
165 – 208
Disordered
Modified residue
179 – 179
Phosphothreonine; by CDK2, CDK4 and MAPK
Alternative sequence
1 – 195
Missing. In isoform 4.
Mutagenesis
179 – 179
T -> V. Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.