Variant position: 170 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 425 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FPPLDDYSHSIPENTNFPAG IEPQSN-IPETPPPGYLSEDGE
Mouse FPPLDDYSHSIPENTNFPAG IEPQSN-IPETPPPGYLSEDG
Rat FPPLDDYSHSIPENTNFPAG IEPQSN-IPETPPPGYLSEDG
Pig FPPLDDYSHSIPENTNFPAG IEPQSN-IPETPPPGYLSEDG
Chicken FPPLDDYSHSIPENTNFPAG IEPQSNYIPETPPPGYLSEDG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 425 Mothers against decapentaplegic homolog 3
137 – 231 Linker
179 – 179 Phosphothreonine; by CDK2, CDK4 and MAPK
1 – 195 Missing. In isoform 4.
179 – 179 T -> V. Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213.
No reference for the current variant in UniProtKB/Swiss-Prot.
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