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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P23921: Variant p.Lys590Gln

Ribonucleoside-diphosphate reductase large subunit
Gene: RRM1
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Variant information Variant position: help 590
Type of variant: help LB/B
Residue change: help From Lysine (K) to Glutamine (Q) at position 590 (K590Q, p.Lys590Gln).
Physico-chemical properties: help Change from large size and basic (K) to medium size and polar (Q)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 590
Protein sequence length: help 792
Location on the sequence: help MWNVTPTDLWDWKVLKEKIA K YGIRNSLLIAPMPTASTAQI
Residue conservation: help 
Human                         MWNVTPTDLWDWKVLKEKIA-KYGIRNSLLIAPMPTASTAQI

Mouse                         MWNVAPTDLWDWKPLKEKIA-KYGIRNSLLIAPMPTASTAQ

Zebrafish                     MWEKTPTDLWDWAALKEKIA-NDGVRNSLLLAPMPTASTAQ

Caenorhabditis elegans        MWGVTPTDQCDWATLRKKIA-KHGIRNSLLMAPMPTASTAQ

Drosophila                    MWDKVPTNLWDWQKLKESIR-MHGVRNSLLVAPMPTASTAQ

Slime mold                    MWNVTPSSRWNWAELKDNIVNKGGLRNSLLIAPMPTASTSQ

Baker's yeast                 MWDQKPYGMWDWDTLRKDIM-KHGVRNSLTMAPMPTASTSQ

Fission yeast                 MWNVNPTDLWDWAELKEKIA-KHGIRNSLLVAPMPTASTSQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 792 Ribonucleoside-diphosphate reductase large subunit
Helix 581 – 591



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.