Sequence information
Variant position: 413 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 571 The length of the canonical sequence.
Location on the sequence:
SSFEAVKDPCFSAKRRKVSP
E SSPDQEETEINFTQKLIDLE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSFEAVKDPCFSAKRRKVSPE SSPDQEETEINFTQKLIDLE
Mouse SVFEEVMDPCFSAKRRKIFIE SSSDQEETEVNFTQKLIDLE
Rat SVFEEVMDPCFSAKRRKIFIT SSLDQEETEVNFTQKLIDLE
Bovine PLSEAIREPCFSAKRRKMFPK ASSDQEETEISLTQKLIDLE
Xenopus laevis IDLEEKAGSCRNVKKKKLSL- -TEDCPVPSV-HAGKLIELE
Xenopus tropicalis LDIEEKAGSCQSVKKKKLSL- -SEDSPVLSV-HAGKFIELE
Zebrafish IELQSEVD--LHSKRPCALL- -RFDSSSEDSPFLSEVAVHE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 571
E3 ubiquitin-protein ligase RNF168
Modified residue
411 – 411
Phosphoserine
Modified residue
414 – 414
Phosphoserine
Modified residue
415 – 415
Phosphoserine
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.