Sequence information
Variant position: 129 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 568 The length of the canonical sequence.
Location on the sequence:
EILALQIYCRNESRGCAEQL
M LGHLLVHLKNDCHFEELPCV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EILALQIYCRNESRGCAEQLM LGHLLVHLKNDCHFEELPCV
Mouse EILALQVYCRNEGRGCAEQLT LGHLLVHLKNECQFEELPCL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 568
TNF receptor-associated factor 3
Literature citations
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
Sato T.; Irie S.; Reed J.C.;
FEBS Lett. 358:113-118(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH TNFRSF5; VARIANT THR-129;
Involvement of CRAF1, a relative of TRAF, in CD40 signaling.
Cheng G.; Cleary A.M.; Ye Z.S.; Hong D.I.; Lederman S.; Baltimore D.;
Science 267:1494-1498(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH TNFRSF5; VARIANT THR-129;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.