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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q13114: Variant p.Met129Thr

TNF receptor-associated factor 3
Gene: TRAF3
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Variant information Variant position: help 129
Type of variant: help LB/B
Residue change: help From Methionine (M) to Threonine (T) at position 129 (M129T, p.Met129Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (M) to medium size and polar (T)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 129
Protein sequence length: help 568
Location on the sequence: help EILALQIYCRNESRGCAEQL M LGHLLVHLKNDCHFEELPCV
Residue conservation: help 
Human                         EILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCV

Mouse                         EILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 568 TNF receptor-associated factor 3
Cross 124 – 124 Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 124 – 124 C -> A. Strong increase in both 'Lys-48' and 'Lys-63'-linked ubiquitination.



Literature citations
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
Sato T.; Irie S.; Reed J.C.;
FEBS Lett. 358:113-118(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH TNFRSF5; VARIANT THR-129; Involvement of CRAF1, a relative of TRAF, in CD40 signaling.
Cheng G.; Cleary A.M.; Ye Z.S.; Hong D.I.; Lederman S.; Baltimore D.;
Science 267:1494-1498(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH TNFRSF5; VARIANT THR-129;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.