Variant position: 894 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1270 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FYVGDAICTIAAATCFPEPF INEGK---RLGYIHRNFAGNRFSD
Mouse FYVGDAVCTISAATCFPEPF ISEGK---RLGYIHRNFAGNR
Bovine FYVGDAICTISAATCFPEPF ISEGK---RLGYIHRNFAGNR
Xenopus laevis FYVGDALCTISAATCFPEPF ISEGR---RLGYVHRNFAGNR
Caenorhabditis elegans LGAGSVMCDVASAMSFPTPF VPREKHHSRLSGTQRKFAGNK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1270 ATP-dependent RNA helicase A
313 – 952 Necessary for interaction with H2AX
831 – 919 HA2
1 – 1035 Missing. In isoform 2.
Human RNA helicase A is homologous to the maleless protein of Drosophila.
Lee C.-G.; Hurwitz J.;
J. Biol. Chem. 268:16822-16830(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PARTIAL PROTEIN SEQUENCE; VARIANT VAL-894;
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