Sequence information
Variant position: 146 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 172 The length of the canonical sequence.
Location on the sequence:
LANFKNYQFFIGENMNPDGM
V ALLDYREDGVTPYMIFFKDG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LA--NFKNYQFFIGENM---NPDGMV ALLDYRE--DGVTPYMIFFKDG
Chimpanzee LA--NFKNYQFFIGENM---NPDGMV ALLDYRE--DGVTPY
Mouse LA--NFNNYQFFIGENM---NPDGMV ALLDYRE--DGVTPF
Rat LA--NFNNYQFFIGENM---NPDGMV ALLDYRE--DGVTPF
Pig LA--NFKNYQFFIGENM---NPDGMV ALLDYRE--DGVTPY
Bovine LA--NFKNYQFFIGENM---NPDGMV ALLDYRE--DGVTPY
Rabbit LA--NFKNYQFYIGENM---NPDGMV ALLDYRE--DGVTPF
Chicken LA--NFKNYQFFVGENM---NPDGMV ALLDFRE--DGVTPY
Xenopus laevis LG--NFKNYQFYTGERM---NPDGMV GLLDYRE--DGITPF
Xenopus tropicalis LG--NFKNYQFYTGERM---NPDGMV ALLDYRE--DGVTPF
Zebrafish LG--NIKNFQFFTGESM---NPDGMI GLLDFRE--DGVTPY
Caenorhabditis elegans LAKDRFKNLAFFIGERAAEGAENGQV AIIEYRDVDGTEVPT
Drosophila LG--RFKELQFFTGESM---DCDGMV ALVEYREINGDSVPV
Baker's yeast IG--SFKDWEFFTGESM---DPDAMV VMLNYRE--DGTTPF
Fission yeast LA--NFKDYDFYIGESM---DPDAMV VLMNYRE--DGITPY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 172
Translationally-controlled tumor protein
Domain
1 – 172
TCTP
Beta strand
146 – 151
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.